Hypertension: pathophysiology and treatment

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Hypertension: Pathophysiology and Treatment

Hypertension is a significant risk factor for heart disease, stroke and other cardiovascular diseases and an estimated 970 million people worldwide suffer from the disease resulting in significant morbidity, mortality and financial burden globally. Despite significant advances in pharmaceutical treatment only 53% achieve targeted blood pressure goals largely due to poor patient compliance compe...

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Hypertension: pathophysiology and treatment

morbidity and mortality because of its association with coronary heart disease, cerebrovascular disease and renal disease. The extent of target organ involvement (i.e. heart, brain and kidneys) determines outcome. North American studies have shown that hypertension is a major contributor to 500 000 strokes (250 000 deaths) and 1 000 000 myocardial infarctions (500 000 deaths) per annum. Nationa...

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Renovascular Hypertension: Pathophysiology, Diagnosis, and Treatment

Renovascular hypertension can result from renal artery lesions involving the main renal artery, or its branches. It is generally felt that the elevation of blood pressure results from excessive systemic vasoconstriction secondary to enhanced renin secretion by one or part of one kidney. Renin secretion is enhanced because of constriction of the renal artery and resultant intrarenal ischemia. Cl...

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Nitric Oxide in Pathophysiology and Treatment of Pulmonary Hypertension

All conditions causing pulmonary hypertension (PH) are characterized by three major changes in the pulmonary vasculature: vasoconstriction, vascular remodeling, and thrombosis [1,2,3]. Vascular remodeling includes muscularization of normally non-muscular peripheral pulmo‐ nary arteries, increase in medial wall thickness of muscular arteries, and increase in vascular connective tissue such as co...

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ژورنال

عنوان ژورنال: Continuing Education in Anaesthesia Critical Care & Pain

سال: 2004

ISSN: 1743-1816

DOI: 10.1093/bjaceaccp/mkh020